Title | Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Howitt MR, Lavoie S, Michaud M, Blum AM, Tran SV, Weinstock JV, Gallini CAnn, Redding K, Margolskee RF, Osborne LC, Artis D, Garrett WS |
Journal | Science |
Volume | 351 |
Issue | 6279 |
Pagination | 1329-33 |
Date Published | 2016 Mar 18 |
ISSN | 1095-9203 |
Keywords | Animals, Chemoreceptor Cells, Eosinophils, Goblet Cells, Helminthiasis, Helminths, Immunity, Mucosal, Interleukin-13, Interleukin-17, Intestinal Diseases, Parasitic, Intestinal Mucosa, Mice, Mice, Inbred C57BL, Mice, Mutant Strains, Microbiota, Protein-Serine-Threonine Kinases, Protozoan Infections, Signal Transduction, Taste, Transducin, Tritrichomonas, TRPM Cation Channels |
Abstract | The intestinal epithelium forms an essential barrier between a host and its microbiota. Protozoa and helminths are members of the gut microbiota of mammals, including humans, yet the many ways that gut epithelial cells orchestrate responses to these eukaryotes remain unclear. Here we show that tuft cells, which are taste-chemosensory epithelial cells, accumulate during parasite colonization and infection. Disruption of chemosensory signaling through the loss of TRMP5 abrogates the expansion of tuft cells, goblet cells, eosinophils, and type 2 innate lymphoid cells during parasite colonization. Tuft cells are the primary source of the parasite-induced cytokine interleukin-25, which indirectly induces tuft cell expansion by promoting interleukin-13 production by innate lymphoid cells. Our results identify intestinal tuft cells as critical sentinels in the gut epithelium that promote type 2 immunity in response to intestinal parasites. |
DOI | 10.1126/science.aaf1648 |
Alternate Journal | Science |
PubMed ID | 26847546 |
Grant List | R01 GM099531 / GM / NIGMS NIH HHS / United States R01 DC003055 / DC / NIDCD NIH HHS / United States R01 CA202704 / CA / NCI NIH HHS / United States K08 AI078942 / AI / NIAID NIH HHS / United States R01 CA154426 / CA / NCI NIH HHS / United States F32DK098826 / DK / NIDDK NIH HHS / United States F31DK105653 / DK / NIDDK NIH HHS / United States |