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Spatial and Temporal Mapping of Human Innate Lymphoid Cells Reveals Elements of Tissue Specificity.

TitleSpatial and Temporal Mapping of Human Innate Lymphoid Cells Reveals Elements of Tissue Specificity.
Publication TypeJournal Article
Year of Publication2019
AuthorsYudanin NA, Schmitz F, Flamar A-L, Thome JJC, Wojno ETait, Moeller JB, Schirmer M, Latorre IJ, Xavier RJ, Farber DL, Monticelli LA, Artis D
JournalImmunity
Volume50
Issue2
Pagination505-519.e4
Date Published2019 02 19
ISSN1097-4180
Abstract

Innate lymphoid cells (ILC) play critical roles in regulating immunity, inflammation, and tissue homeostasis in mice. However, limited access to non-diseased human tissues has hindered efforts to profile anatomically-distinct ILCs in humans. Through flow cytometric and transcriptional analyses of lymphoid, mucosal, and metabolic tissues from previously healthy human organ donors, here we have provided a map of human ILC heterogeneity across multiple anatomical sites. In contrast to mice, human ILCs are less strictly compartmentalized and tissue localization selectively impacts ILC distribution in a subset-dependent manner. Tissue-specific distinctions are particularly apparent for ILC1 populations, whose distribution was markedly altered in obesity or aging. Furthermore, the degree of ILC1 population heterogeneity differed substantially in lymphoid versus mucosal sites. Together, these analyses comprise a comprehensive characterization of the spatial and temporal dynamics regulating the anatomical distribution, subset heterogeneity, and functional potential of ILCs in non-diseased human tissues.

DOI10.1016/j.immuni.2019.01.012
Alternate JournalImmunity
PubMed ID30770247
PubMed Central IDPMC6594374
Grant ListR01 AI074878 / AI / NIAID NIH HHS / United States
R01 AI095466 / AI / NIAID NIH HHS / United States
P01 AI106697 / AI / NIAID NIH HHS / United States
F32 AI134018 / AI / NIAID NIH HHS / United States
F32 DK109630 / DK / NIDDK NIH HHS / United States
K22 AI116729 / AI / NIAID NIH HHS / United States
R01 AI102942 / AI / NIAID NIH HHS / United States
U01 AI095608 / AI / NIAID NIH HHS / United States