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Neuronal regulation of innate lymphoid cells.

TitleNeuronal regulation of innate lymphoid cells.
Publication TypeJournal Article
Year of Publication2019
AuthorsKlose CSn, Artis D
JournalCurr Opin Immunol
Volume56
Pagination94-99
Date Published2019 Feb
ISSN1879-0372
Abstract

The cardinal signs of inflammation suggest a close connection between the nervous system and the immune system. However, the cellular and molecular basis of these interactions remains incompletely defined. Recent research has demonstrated that tissue-resident innate lymphoid cells (ILCs) obtain neuronal signals, particularly at mucosal barriers, where ILCs regulate tissue homeostasis. New developments in our understanding of neuronal regulation of ILCs provide insight into how immune responses in tissues are precisely targeted, spatially regulated, and how ILCs sense environmental changes and disturbance of tissue homeostasis. Therefore, neuronal regulation of immune responses is emerging as an important signaling hub for the maintenance of tissue integrity.

DOI10.1016/j.coi.2018.11.002
Alternate JournalCurr. Opin. Immunol.
PubMed ID30530300