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Neuro-immune Interactions in the Tissues.

TitleNeuro-immune Interactions in the Tissues.
Publication TypeJournal Article
Year of Publication2020
AuthorsChu C, Artis D, Chiu IM
JournalImmunity
Volume52
Issue3
Pagination464-474
Date Published2020 Mar 17
ISSN1097-4180
Abstract

The ability of the nervous system to sense environmental stimuli and to relay these signals to immune cells via neurotransmitters and neuropeptides is indispensable for effective immunity and tissue homeostasis. Depending on the tissue microenvironment and distinct drivers of a certain immune response, the same neuronal populations and neuro-mediators can exert opposing effects, promoting or inhibiting tissue immunity. Here, we review the current understanding of the mechanisms that underlie the complex interactions between the immune and the nervous systems in different tissues and contexts. We outline current gaps in knowledge and argue for the importance of considering infectious and inflammatory disease within a conceptual framework that integrates neuro-immune circuits both local and systemic, so as to better understand effective immunity to develop improved approaches to treat inflammation and disease.

DOI10.1016/j.immuni.2020.02.017
Alternate JournalImmunity
PubMed ID32187517