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Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1.

TitleModulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1.
Publication TypeJournal Article
Year of Publication2019
AuthorsMoeller JB, Leonardi I, Schlosser A, Flamar A-L, Bessman NJ, Putzel GGarbès, Thomsen T, Hammond M, Jepsen CS, Skjødt K, Füchtbauer E-M, Farber DL, Sorensen GL, Iliev ID, Holmskov U, Artis D
JournalJ Exp Med
Volume216
Issue12
Pagination2689-2700
Date Published2019 Dec 02
ISSN1540-9538
Abstract

Host-microbiota interactions are critical in regulating mammalian health and disease. In addition to bacteria, parasites, and viruses, beneficial communities of fungi (the mycobiome) are important modulators of immune- and tissue-homeostasis. Chitin is a major component of the fungal cell wall, and fibrinogen C containing domain 1 (FIBCD1) is a chitin-binding protein; however, the role of this molecule in influencing host-mycobiome interactions in vivo has never been examined. Here, we identify direct binding of FIBCD1 to intestinal-derived fungi and demonstrate that epithelial-specific expression of FIBCD1 results in significantly reduced fungal colonization and amelioration of fungal-driven intestinal inflammation. Collectively, these results identify FIBCD1 as a previously unrecognized microbial pattern recognition receptor through which intestinal epithelial cells can recognize and control fungal colonization, limit fungal dysbiosis, and dampen intestinal inflammation.

DOI10.1084/jem.20182244
Alternate JournalJ. Exp. Med.
PubMed ID31601676
PubMed Central IDPMC6888979
Grant ListF32 AI124517 / AI / NIAID NIH HHS / United States