Title | Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Moeller JB, Leonardi I, Schlosser A, Flamar A-L, Bessman NJ, Putzel GGarbès, Thomsen T, Hammond M, Jepsen CS, Skjødt K, Füchtbauer E-M, Farber DL, Sorensen GL, Iliev ID, Holmskov U, Artis D |
Journal | J Exp Med |
Volume | 216 |
Issue | 12 |
Pagination | 2689-2700 |
Date Published | 2019 Dec 02 |
ISSN | 1540-9538 |
Abstract | Host-microbiota interactions are critical in regulating mammalian health and disease. In addition to bacteria, parasites, and viruses, beneficial communities of fungi (the mycobiome) are important modulators of immune- and tissue-homeostasis. Chitin is a major component of the fungal cell wall, and fibrinogen C containing domain 1 (FIBCD1) is a chitin-binding protein; however, the role of this molecule in influencing host-mycobiome interactions in vivo has never been examined. Here, we identify direct binding of FIBCD1 to intestinal-derived fungi and demonstrate that epithelial-specific expression of FIBCD1 results in significantly reduced fungal colonization and amelioration of fungal-driven intestinal inflammation. Collectively, these results identify FIBCD1 as a previously unrecognized microbial pattern recognition receptor through which intestinal epithelial cells can recognize and control fungal colonization, limit fungal dysbiosis, and dampen intestinal inflammation. |
DOI | 10.1084/jem.20182244 |
Alternate Journal | J. Exp. Med. |
PubMed ID | 31601676 |
PubMed Central ID | PMC6888979 |
Grant List | F32 AI124517 / AI / NIAID NIH HHS / United States |